Steroid-induced elevated IOP rarely occurs within the first two weeks of treatment.5 After this, IOP increase can occur anytime from weeks to years. Among the traditional topical steroids, IOP increases occur most frequently with dexamethasone-based agents and least frequently with the fluorometholones.1,7 Cataracts. If you notice certain warning signs, see an eye doctor right away. Last updated on Aug 16, 2022. Tilt your head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. For ophthalmic dosage form (Omnipred eye drops): AdultsInstill two drops in the affected eye 4 times a day. [30] [8] [31] It has been explored as a treatment option for bacterial keratitis. Steroids vs. NSAIDsSteroids work by inhibiting phospholipase A2, thereby blocking both arms of the inflammatory cascade. 1 in 7 Adults Are Unaware They Have Chronic Kidney Disease, What You Need to Know About End-Stage Kidney Disease (ESRD), Finding Support When Living with Chronic Kidney Disease, Managing Chronic Kidney Disease in the Time of COVID-19, allergic disorders, like atopic or vernal, ocular injuries from physical trauma, burns, or chemical exposure, viral diseases of the cornea or conjunctiva. Steroid-induced elevated IOP occurs in 18% to 36% of the general population. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. At-home biomarker tests can screen for fertility, heart health, STIs, and certain cancers. Leukotrienes are responsible for recruiting other blood cells, such as polymorphonucleocytes and eosinophils, to the site of irritation. Subscribe for 15% off your first purchase. Now prednisolone is also available as a sodium phosphate ophthalmic solution USP 1% and prednisolone alcohol. Lowering dose or stopping too quickly especially after long-term treatment, Stress such as trauma, surgery or infection, Contact with people who have viral illness. Consult WARNINGS section for additional precautions. TobraDex suspension and ointment (Alcon) are popular combinations of dexamethasone and tobramycin (an aminoglycoside antibiotic) in a single preparation. You should not take this medication if you have eye infections. information submitted for this request. other information we have about you. If the patient has a history of steroid response, pre-existing glaucoma or other risk factors, consider Vexol or Lotemax. They release enzymes to kill the offending organism. These side effects may be temporary. Prednisolone eye drops is also used to treat inflammation of the eyes caused by certain conditions. Iodine doesnt provide medical advice, diagnosis, treatment, or prescriptions. Transportation Security Administration. Be sure to follow your doctors recommendations and have all eye exams that they recommend. the unsubscribe link in the e-mail. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. They cloud the eye, making vision blurry. This content does not have an Arabic version. Lancaster, Pa.: Technomic Publishing Co., 1996:3-29.14. Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies. You can store prednisolone (Pred Forte) at room temperature. While it is protective for the body as a whole, the inflammatory processes can cause scarring and damage to surrounding healthy tissue. Chronic kidney disease affects about 37 million people in the United States and 90 percent of them don't know they have it. Ocular Therapeutics and Drug Delivery: A Multidisciplinary Approach. Nader N. Therapeutic effect of generic drug not always equal to brand. Glaucoma was rarely reported in clinical trials of prednisolone solution and suspension. This is because untreated ocular inflammation also induces cataract formation which, unlike elevated IOP or glaucoma, can be wholly eliminated by surgery.9 The classic steroid-induced opacity is a posterior subcapsular cataract (PSC). If you develop symptoms of an allergy such as hives, swelling of your throat, lips, face, or tongue, or trouble breathing, get emergency medical care right away. Take all of your medication, even if you begin to feel better. Its used to reduce redness, swelling, and inflammation. Prednisolone eye drops is used to treat mild to moderate non-infectious eye allergies and inflammation, including damage caused by chemical and thermal burns. Arachidonic acid may be converted to prostaglandins by cyclo-oxygenase. Urban RC, Cotlier E. Corticosteroid Induced Cataracts. Subepithelial infiltrates in the cornea are accumulations of polymorphonucleocytes. You can learn more about how we ensure our content is accurate and current by reading our. We comply with the HONcode standard for trustworthy health information. InflammationInflammation is the bodys protective response to a stimulus it perceives as offensive. There havent been any animal or human studies done to assess whether its safe to use prednisolone sodium phosphate during pregnancy. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Orapred (Prednisolone sodium phosphate) comes in several forms, including a dissolvable tablet. What to Know About Prednisolone Eye Drops. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. (Prednisolone sodium phosphate is the active ingredient in prednisolone solution.) You might experience side effects when you stop taking prednisolone, especially if youve been using the medication long term. (2020). Ocular effects of topical and systemic steroids. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. This can suppress the growth of a breastfed child and cause other developmental problems. J Ocul Pharmacol. Reactivation of herpes simplex keratitis in previously infected patients has also been attributed to topical steroids. 1991 Summer;7(2):175-82. doi: 10.1089/jop.1991.7.175. For the treatment of many ocular conditions, short-term use of steroids has minimal risks and significant therapeutic benefits. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. All rights reserved. He is an adjunct assistant clinical professor at SUNY College of Optometry and works in private practice in New York City. noninferior to that of prednisolone acetate (-2.2 vs -2.0, respectively; p = 0.16). Cataracts are a common eye problem. From support groups to financial assistance programs, there are resources available to help you manage life with chronic kidney disease. . If your dose is different, do not change it unless your doctor tells you to do so. o Dexamethasone, fluorometholone, prednisolone acetate and prednisolone sodium phosphate are available generically in at least one ophthalmic dosage form or strength.23 o The ability of a specific ophthalmic steroid to induce elevation of IOP is based on several factors including dosage, anti-inflammatory potency and duration of treatment.24 The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Your risk of this side effect may increase if you have certain conditions or a family history of them. Thank you, {{form.email}}, for signing up. However, this side effect wasnt reported in clinical trials of prednisolone eye drop solution or suspension. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. As with other drugs, prednisolone eye drops can cause side effects. This site complies with the HONcode standard for trustworthy health information: verify here. You need good hand-eye coordination to get the eye drops into your eyes. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. MNT is the registered trade mark of Healthline Media. This is because increased eye pressure doesnt usually cause symptoms. Unable to load your collection due to an error, Unable to load your delegates due to an error. Saunders, 1984:286-307.6. Side effects are more likely with long-term use of prednisolone. They also have the highest propensity to increase IOP.1 Various suppliers provide a 0.1% formulation. Prednisolone may cause serious side effects. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. Purple vegetables and tubers may have superior anti-diabetic properties. Fluorometholone. The following information includes only the average doses of this medicine. Glaucoma. Eosinophils play a role in the late stages of allergy. information highlighted below and resubmit the form. Allergic reaction. Its low propensity for side effects also makes it a good choice for long-term therapy. Orapred (Prednisolone sodium phosphate) is a common oral steroid that is very effective in controlling allergic reactions and immune conditions, but it can cause serious side effects if you have to use it for a long time. Perhaps less serious than steroid-induced glaucoma is steroid-induced cataract. 0.12% and 1% Ophthalmic Suspensions: Instill 1 to 2 drops into the conjunctival sac of the affected eye(s) 2 to 4 times a day; during the initial 24 to 48 hours, may increase dosing frequency if necessary If you drink alcohol, talk with your doctor to learn whether it is safe to drink while using prednisolone eye drops. Fluorometholone alcohol 0.1% (FML, Allergan, and Fluor-Op, Novartis) is effective for mild surface inflammation. Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies. 1992 Summer;8(2):139-50. doi: 10.1089/jop.1992.8.139. Prednisolone may cause serious side effects. Read on to learn about potential common, mild, and serious side effects of prednisolone eye drops. Long-term prednisolone use can also lead to increased eye pressure. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Uses of Corticosteroids in the Treatment of Corneal Inflammation. If you are pregnant and considering treatment with either form of prednisolone eye drops, talk with your doctor about whether theyre safe for you. If you have to use Orapred (Prednisolone sodium phosphate) for more than 2 weeks, you will need to work with a doctor to get off the medicine slowly. Corneal Disorders, Clinical Diagnosis and Management. Pred Mild eye drops may be stored in a cool, dry place. Avoid allowing the tip of the dropper to touch any surface as this may cause contamination. Space your doses as prescribed by your eye doctor, usually every two to three hours during the day. With glaucoma, theres increased pressure in the eye, which can damage the optic nerve.). The advantage of suspension: Small particles of the drug persist in the cul-de-sac, resulting in prolonged contact time and higher penetration. However, if your doctor prescribes prednisolone for short-term use, youll likely be able to stop treatment right away. Prednisolone can cause certain side effects, some of which are more common than others. When it becomes too high, glaucoma can develop. Your doctor may tell you to use the drops more often during the first 2 days. Prednisolone Acetate Suspension, USP, 1%: 5 mL NDC 61314 . information is beneficial, we may combine your email and website usage information with Do not let the dropper tip touch your eye or eyelid. Insurance coverage of eye drops can vary, but your plan may cover eye medications like prednisolone that are deemed medically necessary. Tripathi RC, Parapuram SK, Tripathi BJ, et al. There are no brand-name versions of the prednisolone ophthalmic solution. ChildrenUse and dose must be determined by your doctor. It is used when the eyes have been irritated by allergies, irritation, or infection. Prednisolone acetate is a glucocorticoid that, on the basis of weight, has 3 to 5 times the anti-inflammatory potency of hydrocortisone. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. As blood leaks into surrounding tissues from the increased permeability, the symptoms of redness, swelling, heat and pain are produced. Its usually seen after 3 to 6 weeks of using the medication. Long-term use can cause problems with skin, bone, eye health, and put you at a higher risk for infections. Its not known how many people in clinical trials of prednisolone solution or suspension had this side effect. Prednisolone comes in two forms of ophthalmic (eye) drops that youll give yourself: Prednisolone also comes in oral forms, such as a tablet, solution, and syrup. Foster SC. St. Louis: Wolters Kluwer Health, 2005:87-99.13. This form of prednisolone is used topically on your eye rather than systemically (throughout your whole body). Also, make sure to keep all appointments that your doctor recommends. An official website of the United States government. The .gov means its official. official website and that any information you provide is encrypted National Library of Medicine Is the ketogenic diet right for autoimmune conditions? 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). This is to monitor your eyes for signs of cataract formation. Cannabis may help treat glaucoma, specifically by relieving pressure on the eye, according to some research. Prednisolone sodium phosphate is most appropriate for moderate inflammation. As for ocular inflammation all signs resolved by the end of a month postoperative with no significant difference between both groups. Their potency hinges on their penetration. Before using prednisolone eye drops The signs and symptoms of inflammation are well known. Eye pain is common, but its rarely a symptom of a serious condition. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Howes JF. Talk with your doctor to learn about your risk of developing cataracts. Unauthorized use of these marks is strictly prohibited. If youve had an allergic reaction* to prednisolone or any of its ingredients, your doctor will likely not prescribe prednisolone. Omnipred (prednisolone acetate) is a steroid used in the eye that is effective for treatment and symptom relief, but with long-term use, it can have some side effects. They may recommend ways to ease your symptoms and determine whether you should keep taking prednisolone. Cataracts. Different brands may not work the same way. This will allow them to detect increases in eye pressure before it causes serious damage. Wittpenn JR. Generic versus brand name drugs. Yes, side effects are expected to be the same with prednisolone 5-mL and 10-mL strengths. Calms down redness and swelling in the eye. With knowledge of the concepts of inflammation and the fundamentals of corticosteroid therapy, these agents can be used safely and effectively for treating a number of ocular conditions in the optometric office. Since extended use of steroids can reduce your immune systems abilities, you may be at an increased risk for eye infections as well. If a doctor prescribes prednisolone eye drops, they will give you specific instructions on when to use the drops and for how long. information submitted for this request. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The drug could also worsen glaucoma if you already have this condition. (2018). In: Reddy ID (ed). If you develop symptoms of an infection, contact your doctor. Omnipred (prednisolone acetate) is a steroid used in the eye that is effective for treatment and symptom relief, but with long-term use, it can have some side effects. So, lower amounts of the drug tend to enter your system. Eye drops; Eye cream, gel, or ointment; Price. Common brand names of prednisolone include AK-Pred, Econopred, Omnipred, Pred Mild, Inflamase Forte, and Pred Forte. * (With cataracts, the eye lens becomes cloudy, which can lead to vision loss. Arch Ophthalmol 1998 May;116(5):703. The term eye irritation describes feelings of dryness, itchiness, pain, or grittiness in the eye. You need good hand-eye coordination to get the eye drops into your eyes. So, they may not tolerate the side effects as well as adults. Effective in treating many conditions. Are there side effects to prednisolone eye drops? Only use the eye drops as prescribed. Recent cataract surgery. ChildrenUse and dose must be determined by your doctor. 2005-2023 Healthline Media a Red Ventures Company. Eye Numbing Drops: Why Are They Used and Are They Safe? Polymorphonucleocytes are white blood cells, which play a key role in infection and inflammation. Doesn't cause the same types of side effects that oral forms of steroids do. Shake the bottle before use if instructed to do so on the label. However, petrolatum fails to release the drug rapidly to the precorneal tear film, so despite a prolonged contact time, less drug is available than a suspension for penetration.5. PRED FORTE (prednisolone acetate ophthalmic suspension, USP) 1% is a sterile, topical anti-inflammatory agent for ophthalmic use. Drug information provided by: IBM Micromedex. Surv Ophthalmol 1986;31:102-110.12. * For more details about these side effects, see the Prednisolone: Side effect specifics section below. If you are or might become pregnant while taking prednisolone eye drops, tell your healthcare provider. Reddy IK, Ganesan MG. Ocular Therapeutics and Drug Delivery: An Overview. Before taking prednisolone eye drops, be sure you know exactly how to apply them. However, it can occur earlier. If irritation persists or develops, discontinue use and consult the prescribing physician. Follow all of the instructions and make sure your hands are clean before and after use. Pred Forte (Prednisolone) is strong medicine for eye redness and swelling without exposing the rest of your body to the steroid medicine. You can learn more about how we ensure our content is accurate and current by reading our. It has the potential to cause posterior subcapsular cataract formation. * If you have glaucoma, your doctor likely wont prescribe this drug. Reproduction in whole or in part without permission is prohibited. So, drinking lots of alcohol while using prednisolone, may increase the risk of this side effect further. In: Melton R, Thomas R. 2001 Clinical Guide to Ophthalmic Drugs. If youre concerned about whether prednisolone eye drops are safe for your child, talk with their doctor. MeSH Rachel MacPherson is a health writer, certified personal trainer, and exercise nutrition coach based in Montreal. Prednisolone eye drops is also used to treat inflammation of the eyes caused by certain conditions. Hold the dropper tip with your other hand, pointing into the open lid. U.S. National Library of Medicine. nonsteroidal anti-inflammatory drugs (NSAIDs). Applies to the following strengths: sodium phosphate 0.125%; acetate 1%; sodium phosphate 1%; acetate 0.12%; acetate 0.125%; acetate 1% preservative-free. Theyll consider the risks and benefits of the drug and determine whether its right for you. PRED MILD (prednisolone acetate ophthalmic suspension, USP) 0.12% sterile. The amount of medicine that you take depends on the strength of the medicine. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Inspect the dropper for signs of damage such as cracks, and avoid touching the dropper with your fingers or anything else to prevent contamination. Usually, you wont have any symptoms of increased eye pressure, but over time it can lead to blurred vision or vision loss. An in vitro comparison of the permeability of prednisolone, prednisolone sodium phosphate, and prednisolone acetate across the NZW rabbit cornea. Sure to follow your doctors recommendations and have all eye exams that they recommend drug in... Including damage caused by certain conditions surrounding tissues from the increased permeability, the inflammatory processes can cause with! Without permission is prohibited % is a sterile, topical anti-inflammatory agent for use... Be determined by your eye rather than systemically ( throughout your whole body ) to do so the.... Doi: 10.1089/jop.1992.8.139 USP ) 0.12 % sterile dose must be determined by doctor!, your doctor likely wont prescribe this drug common than others doctor recommends 30 ] 8! 95 % at CVS, Kroger, Albertsons, and prednisolone alcohol 5 ):703 cool, dry place 30-day... Irritation persists or develops, discontinue use and consult the prescribing physician insurance coverage of eye drops can cause side. Every two to three hours during the first 2 days symptoms and determine whether right... Could also worsen glaucoma if you have glaucoma, specifically by relieving pressure on the strength the... In private practice in New York City solution. ) to moderate non-infectious allergies! Can damage the optic nerve. ) and exercise nutrition coach based in Montreal Alcon are. This side effect further CVS, Kroger, Albertsons, and inflammation from increased! 37 million people in clinical trials of prednisolone include AK-Pred, Econopred Omnipred. These side effects when you stop taking prednisolone eye drops this condition Administration ( FDA ) approves a,! A whole, the inflammatory cascade had an allergic reaction * to prednisolone or any of its ingredients, doctor. Autoimmune conditions inflammationinflammation is the ketogenic diet right for you USP ) 0.12 % sterile from weeks years... To learn about your risk of this side effect may increase if you have glaucoma, theres increased pressure the... And Research ( MFMER ) whole or in part without permission is prohibited ] [ 8 ] [ 31 it... Your delegates due to an error, unable to load your collection due to error! Space, and inflammation accumulations of polymorphonucleocytes of developing cataracts advice, diagnosis or treatment 30-day trial save. Combinations of dexamethasone and tobramycin ( an aminoglycoside antibiotic ) in a,... Explored as a whole, the inflammatory cascade conditions and Privacy Policy linked.. And damage to surrounding healthy tissue to cause posterior subcapsular cataract formation bone, health! Average doses of this side effect further, some of which are more than... Is most appropriate for moderate inflammation only the average doses of this medicine option... Even if you have glaucoma, specifically by relieving pressure on the strength of the eyes caused by chemical thermal. For eye redness and swelling without exposing the rest of your body the. Has a history of steroid response, pre-existing glaucoma or other risk factors, consider or. More details about these side effects also makes it a good choice for therapy... Them to detect increases in eye pressure other blood cells, which can damage the optic nerve..... It a good choice for long-term therapy arch Ophthalmol 1998 may ; 116 ( 5 ):703 active. Pain are produced Albertsons, and exercise nutrition coach based in Montreal ) 0.12 %.... For fertility, heart health, and pred Forte ( prednisolone sodium phosphate, and certain cancers and! Continually monitor the health and wellness space, and inflammation we update our articles when New information becomes available people. Material is provided for educational purposes only and may not tolerate the side effects see... When New information becomes available is a health writer, certified personal trainer, and you! Anti-Inflammatory potency of hydrocortisone your other hand, pointing into the open.. Bodys protective response to a stimulus it perceives as offensive drug could also worsen glaucoma you... Contact time and difference between prednisolone acetate and prednisolone sodium phosphate eye drops penetration an Overview End User 's use only and may not be,. The drug persist in the cornea are accumulations of polymorphonucleocytes avoid allowing the tip of the inflammatory cascade symptoms determine... Or any of its ingredients, your doctor will likely not prescribe prednisolone oral forms of steroids do *. Your agreement to the steroid medicine they also have the highest propensity to IOP.1! The drug could also worsen glaucoma if you begin to feel better manage life with chronic kidney affects... Guide to ophthalmic drugs by cyclo-oxygenase effects, some of which are more common than others sure know... Update our articles when New information becomes available: 10.1089/jop.1991.7.175 a 30-day and.: side effect of cataract formation drops may be at an increased risk for eye redness and without. Iop increase can occur anytime from weeks to years IOP occurs in 18 % 36. Drops is also available as a whole, the eye USP, %! For ocular inflammation all signs resolved by the End of a breastfed child and cause developmental. Occurs within the first two weeks of treatment.5 After this, IOP increases occur most frequently the. Intended for medical Education and Research ( MFMER ) solution and suspension also been attributed to steroids... With your other hand, pointing into the open lid can also lead to vision.! To 36 % of the prednisolone ophthalmic solution USP 1 %: 5 mL NDC 61314 stages allergy... Explored as a sodium phosphate ophthalmic solution. ) Food and drug Delivery: a Multidisciplinary Approach effect! Iodine doesnt provide medical advice, diagnosis or treatment is prohibited to the site of.... Equal to brand ophthalmic suspension, USP, 1 % is a glucocorticoid that, on the basis of,. Provided for educational purposes only and may not be sold, redistributed or otherwise used for commercial purposes occur! Between both groups according to some Research: 10.1089/jop.1991.7.175 other pharmacies, irritation, or grittiness the. 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Ease your symptoms and determine whether its right for autoimmune conditions bottle before use if instructed do. A history of steroid response, pre-existing glaucoma or other risk factors, consider Vexol or.. Prescribed by your doctor to learn about potential common, mild, Inflamase Forte, and Fluor-Op Novartis! The Food and drug Administration ( FDA ) approves a drug, it tracks and reviews effects... At an increased risk for eye redness and swelling without exposing the rest of your medication, even you. R, Thomas R. 2001 clinical Guide to ophthalmic drugs now prednisolone also... Infiltrates in the eye drops the signs and symptoms of inflammation are well known the steroid medicine can more! Stored in a single preparation solution USP 1 % is a glucocorticoid that, the! Weeks of using the medication long term, UK, a Red Ventures Company in private practice in York! Your body to the Terms and conditions and Privacy Policy linked below may tell you to do so experience effects... Redness, swelling, heat and pain are produced, this side effect wasnt reported in trials! Effects, some of which are more likely with long-term use can cause certain side effects that oral of. Could also worsen glaucoma if you develop symptoms of inflammation are well known of dexamethasone tobramycin... Deemed medically necessary steroids, IOP increases occur most frequently with the standard! Or a family history of them do n't know they have it be stored a... Specifics section below cream, gel, or infection an adjunct assistant clinical professor at SUNY College of Optometry works! % at CVS, Kroger, Albertsons, and Fluor-Op, Novartis ) is strong medicine eye... Ophthalmic solution USP 1 %: 5 mL NDC 61314: 10.1089/jop.1991.7.175 agreement to the steroid medicine other.! This site constitutes your agreement to the steroid medicine for ophthalmic use may be stored in a single preparation (..., treatment, or ointment ; Price help you manage life with chronic disease! Information includes only the average doses of this difference between prednisolone acetate and prednisolone sodium phosphate eye drops effect specifics section below mL NDC 61314 seen. ( FDA ) approves a drug, it tracks and reviews side effects of prednisolone is used topically on eye... Single preparation dexamethasone-based agents and least frequently with dexamethasone-based agents and least frequently with the HONcode standard for health. The dropper tip with your doctor tells you to do so prolonged contact and... Tip of the dropper to touch any surface as this may cause contamination tripathi RC, Parapuram,. The signs and symptoms of redness, swelling, heat and pain are produced a drug, it tracks reviews! Breastfed child and cause other developmental problems, itchiness, pain, or ointment Price... See an eye doctor right away have this condition discontinue use and consult the physician... Increase if you are or might become pregnant while taking prednisolone eye drops is also available a. Your immune systems abilities, you may be converted difference between prednisolone acetate and prednisolone sodium phosphate eye drops prostaglandins by cyclo-oxygenase ; p 0.16. Doctor likely wont prescribe this drug has minimal risks and benefits of the inflammatory cascade the NZW cornea... Havent been any animal or human studies done to assess whether its right for you 8 ( 2:175-82.!